For the testing of skin irritation with the standard Draize test, rabbits are used. The chemical is applied to the rabbit skin and usually kept in contact for 4 hours. The degree of skin irritation is scored for erythema, eschar and edema formation and corrosive action. These dermal irritation observations are repeated at various intervals after the chemical has been removed. Mucous membrane irritation is measured in a similar manner. Site specific mechanical responses within the respiratory tract and eyes are measured, and a chemical is classified as an irritant based on the conclusions of these tests.
Source: MBDC
Category: Green